SMRTR Science & EngineeringAug 20, 2026Interesting Engineering

World’s first personalized mRNA cancer vaccine succeeds in US Phase 3 trial

SMRTR summary

Moderna and Merck's personalized mRNA cancer vaccine, intismeran, successfully met its Phase 3 trial goals when combined with Keytruda, cutting melanoma's return risk by 49% over five years. Custom-built for each patient's tumor, this breakthrough could reshape cancer treatment, with trials expanding to lung, bladder, and kidney cancers.

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