SMRTR Science & EngineeringJun 18, 2026Quanta Magazine

Why the Human Genome’s Tangled Physicality May Confound AI

SMRTR summary

The idea that DNA is a simple blueprint for life may be misleading, and that misunderstanding could limit what AI can accomplish in biology. While scientists have long treated the genome like a readable code, the physical shape and tangled three-dimensional structure of DNA inside cells also plays a critical role in how genes work — something AI models struggle to account for.

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