SMRTR Science & EngineeringJul 17, 2025Interesting Engineering

‘Spring cleaning’ process unlocks human eggs’ mystery for decades-long survival

SMRTR summary

Human eggs maintain longevity by slowing down internal waste disposal systems. A study of over 100 donated eggs revealed that lysosomes, proteasomes, and mitochondria operate at 50% lower activity compared to surrounding cells, further decreasing as eggs mature. This minimalist strategy conserves energy and reduces harmful byproducts, allowing eggs to remain pristine for decades. The discovery could lead to improved IVF success rates by maintaining eggs' naturally quiet state.

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