Small Molecules Have More Information per Atom Than Biologics
SMRTR summary
Small molecules pack far more information per atom than proteins or DNA-based drugs — up to 5.7 bits per atom versus 0.52 for proteins. This makes them powerful but hard to synthesize and nearly impossible for AI models to accurately simulate, meaning physics-based drug design methods will remain essential for the foreseeable future.
SMRTR provides this summary for quick context. The original article belongs to Hacker News.
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