Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways
SMRTR summary
Cambridge researchers discovered why both activating and blocking the same brain receptor, called GIPR, can lead to weight loss. Activating GIPR in the brainstem reduces appetite, while blocking it in the hypothalamus releases a "brake" that strengthens fullness signals. Both pathways can also boost the effectiveness of existing GLP-1 drugs like Ozempic, potentially leading to better obesity treatments with fewer side effects.
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