Scientists reverse kidney damage in mice, hope for humans next

University of Utah researchers discovered that fatty molecules called ceramides cause acute kidney injury by damaging energy-producing mitochondria in kidney cells. Using a drug candidate that alters ceramide processing, scientists completely reversed kidney damage in mice, protecting mitochondrial structure and maintaining normal kidney function even under severe stress conditions. The breakthrough could lead to preventive treatments for high-risk patients undergoing procedures like heart surgery, where about 25% develop acute kidney injury.