SMRTR Science & EngineeringJun 30, 2025Science Daily

Scientists just found a sugar switch that protects your brain from Alzheimer's

SMRTR summary

A Buck Institute study reveals brain sugar metabolism's crucial role in fighting Alzheimer's and dementia. Researchers found that breaking down glycogen in neurons protects against toxic protein buildup. Tau protein binds to glycogen, hindering its breakdown and promoting disease progression. Restoring glycogen phosphorylase activity reduced tau-related damage in fruit flies and human neurons. This research suggests new treatment possibilities for neurodegenerative diseases by targeting brain sugar metabolism.

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