SMRTR Science & EngineeringJul 12, 2025Science Daily

Scientists just found 200+ hidden proteins that may drive Alzheimer’s

SMRTR summary

Johns Hopkins researchers identified over 200 misfolded proteins in rats potentially linked to age-related cognitive decline, challenging the focus on A-beta and tau amyloids in Alzheimer's and dementia. Comparing cognitively impaired and healthy rats, they found numerous misfolded proteins in impaired rats that remained properly folded in healthy ones. This discovery could lead to new therapeutic targets for memory loss and cognitive decline. Further research will explore how these proteins evade cellular surveillance systems.

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