Scientists find the genetic switch that makes pancreatic cancer resist chemotherapy
SMRTR summary
Duke-NUS researchers discovered that a gene called GATA6 acts as a molecular switch determining whether pancreatic cancer cells respond to chemotherapy or resist it, with higher GATA6 levels making tumors more organized and treatable. The team found that blocking the KRAS-ERK pathway can restore GATA6 levels and make resistant tumors sensitive to treatment again.
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