Scientists discover the enzyme that lets cancer rapidly rewire its DNA
SMRTR summary
UC San Diego scientists identified N4BP2, the enzyme that triggers chromothripsis, a catastrophic genetic event where chromosomes shatter and reassemble incorrectly, allowing cancer cells to rapidly evolve and resist treatment. This discovery reveals the molecular spark behind one of cancer's most aggressive survival tactics, occurring in about 25% of all cancers, and opens new treatment possibilities.
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