Scientist Who Was Offline 'Living His Best Life' Stunned by Nobel Prize Win
SMRTR summary
Fred Ramsdell was backpacking in Wyoming's mountains when he won the 2025 Nobel Prize in Physiology or Medicine, only learning about his victory when his wife's phone exploded with messages after they regained cell service. Ramsdell, along with co-winners Mary Brunkow and Shimon Sakaguchi, discovered how the body's immune system learns to spare its own tissues by studying mutated mice from a World War II radiation experiment at Oak Ridge National Laboratory. Their breakthrough identified the gene responsible for immune tolerance, paving the way for today's cell therapies that retrain immune cells to fight cancer and other diseases.
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