SMRTR Science & EngineeringApr 30, 2026Ars Technica

Researchers try to cut the genetic code from 20 to 19 amino acids

SMRTR summary

Researchers from Columbia and Harvard used AI tools to engineer bacteria with a ribosome that works without isoleucine, one of the 20 amino acids all life uses. The redesigned bacteria survived and grew at 60% the normal rate, suggesting a reduced genetic code is possible, offering clues about how early life may have evolved.

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