SMRTR Science & EngineeringMay 7, 2025Science Daily

Piecing together the brain puzzle

SMRTR summary

Scientists at ISTA and Google Research developed LICONN, a new microscopy method that reconstructs brain tissue with synaptic connections between neurons. This breakthrough technique uses hydrogel expansion and AI to achieve ultra-high resolution imaging of brain structures using standard light microscopes. LICONN enables visualization of complex molecular machinery alongside neuronal structures, potentially advancing our understanding of brain function in health and disease.

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