SMRTR Science & EngineeringSep 22, 2025Interesting Engineering

New RNA mapping technique could potentially analyze Einstein’s preserved brain

SMRTR summary

Chinese researchers have developed Stereo-seq V2, an advanced RNA-mapping tool that can analyze previously unusable biological samples, including decade-old cancer tissues stored in poor conditions. The technology improves RNA capture efficiency and uses random-primed chemistry to achieve full gene-body coverage in degraded samples. This breakthrough unlocks valuable information from millions of formalin-fixed, paraffin-embedded samples in hospitals worldwide, offering new possibilities for cancer research, rare disease studies, and pathogen-immune system interactions.

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