SMRTR Science & EngineeringJul 22, 2025Live Science

Male birth control pill passes early safety test, with more trials underway

SMRTR summary

A hormone-free male birth control pill, YCT-529, has passed its initial safety test in humans. The drug blocks a protein essential for sperm production. A small trial of 16 men showed no significant side effects across various doses. This allows for larger trials to evaluate safety and effectiveness. If approved, it would be the first reversible male contraceptive pill, enhancing family planning options. Preclinical tests in animals demonstrated 99% effectiveness, with fertility returning after discontinuation.

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