SMRTR Science & EngineeringJul 29, 2025Interesting Engineering

Lab-grown mini-brain with blood vessels could help slash 90% neurodrug failure rate

SMRTR summary

Johns Hopkins researchers have created a multi-region brain organoid (MRBO) with connected neural tissues and basic blood vessels, mimicking a 40-day-old human fetal brain. This breakthrough could advance the study of neuropsychiatric disorders and improve drug development. By more accurately reflecting human brain development, these organoids may help reduce the high failure rate of neuropsychiatric drugs in clinical trials. The technology enables the study of complex neurological diseases affecting the entire brain and testing new treatments on a more human-like model.

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