SMRTR Science & EngineeringMar 7, 2025Interesting Engineering

Greenland sharks can live for 400 years without getting cancer, thanks to their DNA

SMRTR summary

Greenland sharks, living up to 400 years without cancer, possess enhanced DNA repair mechanisms and robust immune defenses. A genomic study revealed an abundance of genes related to the NF-kB pathway, regulating inflammation, immunity, and cell survival. Their genomic stability over centuries may result from efficient DNA repair enzymes. These findings could inspire new cancer treatments and lifespan-extending therapies. The study also identified adaptations for deep ocean survival.

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