SMRTR Science & EngineeringNov 4, 2025Live Science

'As if a shudder ran from its brain to its body': The neuroscientists that learned to control memories in rodents

SMRTR summary

Neuroscientist Steve Ramirez and his lab partner developed a groundbreaking technique to artificially control memories in rodents by using laser light to activate specific brain cells. When they optogenetically stimulated positive memories in mice showing depression-like behaviors, the animals immediately returned to normal activity levels, preferring sugar water over regular water. Remarkably, chronic activation of positive memories for one week permanently reversed symptoms and promoted new brain cell growth, suggesting memories could serve as powerful therapeutic tools.

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