SMRTR Science & EngineeringJul 30, 2025Science News

A molecule produced by gut microbes may help spur heart disease

SMRTR summary

A molecule called imidazole propionate (ImP), produced by gut microbes breaking down histidine, has been linked to early cardiovascular disease. Researchers found higher blood levels of ImP in people with early plaque buildup and demonstrated in mice how ImP contributes to atherosclerosis by triggering inflammation. This discovery opens up potential new treatment avenues for cardiovascular disease that don't rely on lowering cholesterol.

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